Glomerulonephritis, Nephrotic & Nephritic Syndrome

Table of Contents

Introduction

Glomerulonephritis

Glomerulonephritis consists of a set of renal diseases presenting as a combination of hematuria, proteinuria, edema, and hypertension. Glomerulonephritis can be caused by a variety of disorders which are caused by glomerular injury with subsequent inflammation or potential renal failure. The pathogenesis of glomerulonephritis is not well-known, but it is considered to be an autoimmune response to etiologic agents (infections) caused by genetic factors. This immunologic response triggers biological processes such as leukocyte, complement activation, and release of cytokines which trigger the inflammation or injury of the kidney (Niaudet, 2018).

Main body

There are two common types of glomerulonephritis – acute and chronic with pathophysiology differing slightly between them. In acute, the streptococcal neuraminidase modifies the host immunoglobulin G (IgG), combining with antibodies that collect in the glomeruli. Cellular proliferation occurs structurally leading to an increase in the number of cells, becoming either endocapillary or extra capillary.

Furthermore, the glomerular basement membrane thickens. In chronic glomerulonephritis, there is a reduction of the nephron mass in the injury leading to hypertrophy and hyperfiltration attempting to minimize functional nephron loss. A decline in GFR causes a rise in serum creatinine levels (Azotemia) which can lead to reductions in the production of erythropoietin, Vitamin D, as well as a reduction in excretion that may cause acidosis, hypertension, or edema (Gaut, Mueller, & Liapis, 2017).

Physical and symptom manifestations of glomerulonephritis vary on type, progression, and severity of the condition. Symptoms of acute glomerulonephritis include bloating in the face, bloody or brown urine, unusual urinating activity, and high blood pressure. Chronic glomerulonephritis commonly develops more subtly with slow-progressing symptoms such as swelling and high blood pressure, abdominal pain, nosebleeds, frequent urination, as well as an excess of protein in the urine that may lead to changes in its consistency (Ponticelli & Glassock, 2019).

Nephrotic Syndrome Nephritic Syndrome
Caused primarily by non-proliferative types of glomerulonephritis Associated with proliferative types of glomerulonephritis
Symptoms of proteinuria (>3.5g) Characterized by hematuria, with minimal proteinuria (<3.0g) and low urine volume
Damage to the glomeruli leads to a general edema Causes inflammation to the glomeruli and renal dysfunction
Hypoalbuminemia commonplace alongside proteinuria Hypoalbuminemia present with albumin transferring from blood to urine
Worse prognosis, especially in patients with heavy proteinuria or renal insufficiency. Spontaneous remissions are possible with minimal change disease with a prognosis for recovery. Meanwhile, with primary focal segmental
glomerulosclerosis remissions are rare, but the renal prognosis is poor
Better prognosis for recovery of renal function with infrequent remissions, especially with post-streptococcal glomerulonephritis, depending on etiology

Conclusion

The nephrotic syndrome appears as a primary (idiopathic) renal disease in combination with other systemic conditions. The syndrome results in non-inflammatory damage to the glomerular capillary wall. The underlying glomerular disease leads to proteinuria due to modifications in the selectivity of the glomerular capillary wall. As a result, permeability increases to plasma proteins with loss of albumin in the urine as well as proteins carrying hormones, Vitamin D, and clotting inhibitors.

Nephritic syndrome is characterized by glomerular inflammation, the degree of which impacts the severity of renal dysfunction and clinical manifestations. Immunologic perturbations which are common in glomerulopathies can be seen with either antibody binding to structural components or formation of antigen-antibody complexes that cause glomerular injury. The filtration barrier begins to malfunction resulting in inflammation and there is salt retention leading to volume expansion, hypertension, and edema (Dylewski, Kooienga, & Teitelbaum, 2018).

References

Dylewski, J., Kooienga, L., & Teitelbaum, I. (2018). Chapter 24: Nephrotic syndrome versus nephritic syndrome. In E. V. Lerma, M. H. Rosner, & M. A. Perazella (Eds.), CURRENT diagnosis & treatment: Nephrology & hypertension (2ed.) (211-216). New York, NY: McGraw Hill Education.

Gaut, J. P., Mueller, S., & Liapis, H. (2017). IgA dominant post-infectious glomerulonephritis update: pathology spectrum and disease mechanisms. Diagnostic Histopathology, 23(3), 126-132. Web.

Niaudet, P. (2018). . Web.

Ponticelli, C., & Glassock, R. J. (2019). Treatment of primary glomerulonephritis. Oxford, England: Oxford University Press.

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
$0.00
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with My Homework Geeks
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
Testimonials
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
11,595
Customer reviews in total
96%
Current satisfaction rate
3 pages
Average paper length
37%
Customers referred by a friend
OUR GIFT TO YOU
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat
Live ChatWhatsApp